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Gamma-Fibrinogen (377-395) - ANA62128 - 1 mg - AnaSpec - proteins & peptides

Gamma-Fibrinogen (377-395)
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Size: 1 mg
£164.00
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Catalogue number:
ANA62128
Name:
Gamma-Fibrinogen (377-395)
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This fibrinogen-derived inhibitory peptide attenuates microglia activation and suppresses relapsing paralysis in multiple sclerosis (MS). Fibrinogen is a regulator of microglia activation and interaction of fibrinogen with the microglia integrin receptor Mac-1. Because blocking fibrinogen–Mac-1 interactions affects the pro-inflammatory but not the pro-coagulant properties of fibrinogen, targeting this gamma- fibrinogen epitope could represent a potential therapeutic strategy for MS and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation.

Data sheet:

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Product Type:
Proteins & Peptides
Alternative Names:
YSMKETTMKIIPFNRLSIG
Storage Temp:
-20°C
Compound Purity:
Peak Area by HPLC ≥95%
Molecular Weight:
2229.7
Reference:
Adams, R. et al. J. Exp. Med. Published online 5 March 2007 doi:10.1084/jem.20061931
UNSPSC Code:
12352202
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