This peptide is the mutant form of the b-Amyloid peptide (1-40). The mutation within the coding region of the β-Amyloid precursor protein (APP) results in substitution of glycine for alanine in this peptide. Presenile dementia is present in a pattern consistent in the family of British origin with the dominant inheritance of Flemish APP mutation. The impact of the point mutation A21G on b-Amyloid structure and dynamics varies from b-Amyloid (1-40) to b-Amyloid (1-42).
Proteins & Peptides
Peak Area by HPLC ≥95%
Brooks, W. et al. Neurol. 63, 1613 (2004); Van Nostrand, W. et al. J. Biol. Chem. 276, 32860 (2001); A. Huet and P. Derreumaux Biophys. J. 91, 3829 (2006).