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[Lys22]-beta-Amyloid (1-40), Italian Mutation, Human

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Catalogue number:
ANA62147
Size:
0.5 mg
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This is amino acids 1 to 40 fragment of the beta-amyloid peptide with lysine substituted for glutamic acid at position 22, found in Italian families. The Italian mutation of beta-amyloid 1-40 (E22K) aggregates more rapidly and with more potent neurotoxicity than wild-type beta-amyloid 1-40. The formation of a salt bridge between Lys-22 and Asp-23 in the minor conformer might be a reason why E22K-beta-amyloid 40 is more pathogenic than wild-type beta-amyloid 40.

Product Type:

Proteins & Peptides

Storage Temp:

-20°C

Compound Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

4328.9

Reference:

Masuda, Y. et al. Bioorg. Med. Chem. 13, 6803 (2005).

UNSPSC Code:

12352202

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