*

[Lys22]-beta-Amyloid (1-42), Italian Mutation, Human

Supplier:
Catalogue number:
ANA62148
Size:
0.5 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£392.00 Shipping is calculated in checkout

This is amino acids 1 to 42 fragment of the beta-amyloid peptide, with lysine substituted for glutamic acid at position 22 found in Italian families with Alzheimer's disease. The Italian mutation of beta -amyloid 1 to 42 (E22K) aggregates more rapidly and with more potent neurotoxicity than wild-type beta-amyloid (1-42). The formation of a salt bridge between Lys22 and Asp23 in the minor conformer might be a reason why E22K is more pathogenic than wild-type beta-amyloid (1-42).

Product Type:

Proteins & Peptides

Storage Temp:

-20°C

Compound Purity:

Peak Area by HPLC ≥95%

Molecular Weight:

4513.2

Reference:

Masuda, Y. et al. Bioorg. Med. Chem. 13, 6803 (2005).

UNSPSC Code:

12352202

Sorry - there are no images available for this product.