SEC inhibitor KL-2
Catalogue number:
HY-123972-1mg
Supplier:
Size:
1 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
900308-51-2
Purity:
99.49
Molecular Formula:
C17H13ClFNO3
Molecular Weight:
333.74
Mass Spectrometry:
Reference Materials
Alternative Names:
KL-2
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 µM[1].
