Guggulsterone
Catalogue number:
HY-107738-1mL
Supplier:
Size:
1 ml
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
95975-55-6
Purity:
99.83
Molecular Formula:
C21H28O2
Molecular Weight:
312.45
Alternative Names:
Z/E-Guggulsterone
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt[1][2]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 µM and 39.05 µM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively[3]. 10mM
