trans-Cyclohexane-1,2-diol
Catalogue number:
HY-W010514-1mL
Supplier:
Size:
1 ml
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1460-57-7
Purity:
99.94
Molecular Formula:
C6H12O2
Molecular Weight:
116.16
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC). By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells[1][2]. 10mM
