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  3. rMouse CCL7 Protein
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rMouse CCL7 Protein

Catalogue number:
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010-001-V76-0100
Supplier:
Rockland Immunochemicals
Size:
100 µg
Product is available in:
  • UK
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£767.00
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Purity:

Monocyte Chemotactic protein-3 (CCL7) purity was d

Alternative Names:

Intercrine/chemokine MARC, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3 (MCP-3), Protein FIC, Small-inducible cytokine A7

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Product Description:

Monocyte Chemotactic Protein 3 (MCP-3) , also called CCL7, is produced by macrophages and some tumor cell lines. MCP-3 signals through three different G protein-coupled receptors, CCR1, CCR2, and CCR3. CCL7 chemoattracts monocytes and can regulate macrophage function. Recombinant mouse MCP-3 is a non-glycosylated protein, containing 74 amino acids, with a molecular weight of 8.5 kDa. Monocyte Chemotactic Protein-3 Recombinant Protein has been tested by SDS-PAGE and biological activity and is suitable as a control for polyclonal or monoclonal anti-Monocyte Chemotactic Protein-3 in immunological assays.

SDS-PAGE of Mouse Monocyte Chemotactic P
SDS-PAGE of Mouse Monocyte Chemotactic Protein-3 (CCL7) Recombinant Protein. Lane 1: Molecular weight marker. Lane 2: 1 µg Mouse MCP-3 in non-reducing conditions (-). Lane 3: 1 µg Mouse MCP-3 in reducing conditions (+). Mouse MCP-3 has a predicted MW of 8.5 kDa.
Bioactivity of Mouse Monocyte Chemotacti
Bioactivity of Mouse Monocyte Chemotactic Protein-3 (CCL7) Recombinant Protein. Human THP-1 cells were allowed to migrate to Mouse MCP-3 at (0, 0.1, 1, 10, 100 and 1000 ng/mL). After 45 minutes, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above. Significant increases in migration over basal levels were seen in response to Mouse MCP-3 starting at 1000 ng/mL. This value is comparable to expected ranges of a chemotactic response of primary human monocytes.