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rHuman Fractalkine (CX3CL1) Protein

Catalogue number:
009-001-H49-0020
Size:
20 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
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Purity:

Fractalkine (CX3CL1) purity was determined to be g

Alternative Names:

C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, Neurotactin, Small-inducible cytokine D1

Product Description:

Fractalkine, also known as CX3CL1, is an atypical chemokine that was the first of a fourth chemokine motif (CX3C) . It is thought to function as a T cell and monocyte chemotractant and is produced by non-haemopoietic cells. Fractalkine is made in a soluble and membrane bound form in activated endothelial cells which is thought to promote adhesion of leukocytes. Recombinant human Fractalkine is a non-glycosylated protein, containing 76 amino acids, with a molecular weight of 8.6 kDa. Fractalkine Recombinant Protein has been tested by biological activity and is suitable as a control for polyclonal or monoclonal anti-Fractalkine in immunological assays.

Bioactivity of Human Fractalkine (CX3CL1
Bioactivity of Human Fractalkine (CX3CL1) Recombinant Protein. Human PBMCs were allowed to migrate to Human Fractalkine at (0, 0.1, 1, 10 , 100 and 1000 ng/mL). After 4 hours, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above. Significant increases in migration over basal levels were seen in response to Human Fractalkine detectable starting at between 10-100 ng/mL.