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  3. rHuman Myostatin Propeptide Protein
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rHuman Myostatin Propeptide Protein

Catalogue number:
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009-001-W02-0005
Supplier:
Rockland Immunochemicals
Size:
5 µg
Product is available in:
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£154.00
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Purity:

Myostatin propeptide purity was determined to be g

Alternative Names:

Myostatin

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Product Description:

Myostatin (GDF-8) , a member of the TGF-β superfamily, is a potent and specific negative regulator of skeletal muscle mass. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide acting as a negative regulator of myostatin. Recombinant human Myostatin Propeptide is a non-glycosylated protein, containing 244 amino acids, with a molecular weight of 27.8 kDa. Myostatin Propeptide Recombinant Protein has been tested by SDS-PAGE and biological activity and is suitable as a control for polyclonal or monoclonal anti-Myostatin Propeptide in immunological assays.

SDS-PAGE of Human Myostatin Propeptide a
SDS-PAGE of Human Myostatin Propeptide and Myostatin Recombinant Protein. Lane 1: 1 µg Human Myostatin Propeptide in reducing conditions (+). Lane 2: 1 µg Human Myostatin in reducing conditions (+). Lane 3: 1 µg Human Human Myostatin Propeptide in non-reducing conditions (-). Lane 4: 1 µg Human Human Myostatin in non-reducing conditions (-). Lane 5: Molecular weight marker. Human Myostatin Propeptide is predicted to be a disulfide-linked homodimer of 27.8 kDa and Myostatin is predicted to be a non-covalently linked homodimer with a MW of 25 kDa .
Bioactivity of Human Myostatin Propeptid
Bioactivity of Human Myostatin Propeptide Recombinant Protein. MPC-11 cells were cultured with 50 ng/mL Human Myostatin and serial dilutions of Human Myostatin Propeptide from 0-1 ug/mL. Cell proliferation was measured after 65 hours and the linear portion of the curve was us used to calculate the ED50. The ED50 of Human Myostatin Propeptide is 0.09-0.14 ug/mL. This typical expected value for this activity is 10-40 ng/mL.