TRIP12 Antibody
ELISA, Immunohistochemistry, IF Microscopy, Western Blot
Rabbit
H. sapiens (Human); Mus musculus (Mouse); Rat
IgG
Polyclonal
Anti-TRIP12 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 18 amino acid peptide near the C-terminus of human
TRIP12 Antibody, ULF, TRIP-12, KIAA0045, ULF, E3 ubiquitin-protein ligase TRIP12, E3 ubiquitin-protein ligase for Arf
Thyroid hormone receptors (TRs) are transcription factors that regulate the expression of specific genes in a hormone-dependent manner (1) . TRIP12 (thyroid hormone receptor interactor 12) is an ATP-dependent E3 ubiquitin ligase involved in the human ubiquitin fusion degradation (UFD) pathway and also modulates the NEDD8 pathway (2,3) . TRIP12 contains one WWE domain and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain suggested to contain a noncovalent ubiquitin-binding site (4) . TRIP12 acts as a key regulator of DNA damage response and the ubiquitin ligase activity of TRIP12 is essential for mouse development (5) . Anti-TRIP12 Antibody has been tested for use in ELISA, Western Blotting, Immunohistochemistry, immunocytochemistry, and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 220 kDa in Western Blots of specific cell lysates and tissues.
