BASSOON Antibody

Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntingtin, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to colocalize with GABA (A) and glutamate (GluR1) receptors. Anti-Bassoon Antibody is tested for use in WB and IHC. Expect a band approximately ~420kDa on specific lysates corresponding to the molecular mass of Bassoon. Multiple isoforms can be detected. Specific conditions for reactivity should be optimized by the end user. Product provided in PBS pH 7.4.