TCC52 Antibody
ELISA, Western Blot
Chicken
H. sapiens (Human); Mus musculus (Mouse); Rat
IgY
Polyclonal
Anti-TCC52 antibody was prepared from chicken egg fractions produced by repeated immunizations with a 15 amino acid synthetic peptide near the C-termi
TCC52 Antibody, CT102, TCC52, WDR40A, KIAA1892, DDB1- and CUL4-associated factor 12, Centrosome-related protein TCC52, Testis cancer centrosome-related protein, WD repeat-containing protein 40A
Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors. One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time. Anti-TCC52 Antibody has been tested for use in ELISA, Western Blotting, Immunocytochemistry. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 51 kDa in Western Blots of specific cell lysates and tissues.
