Caldesmon (smooth) Antibody

Caldesmon is a potential actomyosin regulatory protein found in smooth muscle and nonmuscle cells. The predicted smooth-muscle polypeptide is 793 amino acids long. The high molecular weight caldesmon (h-CaD) is predominantly expressed in smooth muscles, whereas the low molecular weight caldesmon (l-CaD) is widely distributed in nonmuscle tissues and cells. Hayashi et al. (1992) demonstrated that the human CDM gene is composed of 14 exons. This antibody is suitable for researchers interested in neurodegenerative diseases, developmental signaling, GPCR signaling, and MAK Kinase Signaling. Anti-Caldesmon is tested for Immunohistochemistry -P and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~93.2 kDa with isoforms ~60kDa corresponding to the appropriate cell lysate or extract.