Neuromodulin phospho S41 Antibody

Gap-43 pS41 antibody detects phosphorylated GAP43 at position S41. Gap43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration. There is also evidence from knockout animals that Gap-43 serves to amplify pathfinding signals from the growth cone. Gap-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by protein kinase C modulates the interaction of Gap-43 with actin and may also affect neurotransmitter release during forms of plasticity like LTP. Anti-Gap-43 pS41 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, and Signal Transduction research. Anti-GAP43 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 50 kDa in size corresponding to neuromodulin protein phosphorylated at Ser41 in the appropriate cell lysate or extract. In some tissues, the antibody also recognized a higher molecular weight protein that may be an aggregate or oligomer.