Clavesin Antibody

Clavesin antibody recognizes clavesin (clathrin vesicle associated Sec14 protein) which is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects. Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state. Anti-Clavesin antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research. Anti-Clavesin antibody is tested for use in ELISA, Western Blotting and ICC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 35 kDa in size corresponding to clavesin protein doublet in Western Blots of rat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are clavesin 1 and 2, respectively.