Retinoic Acid Receptor alpha Antibody

Retinoic Acid Receptor alpha antibody detects RAR alpha. Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The retinoid X receptors (RXRs) family (RXRα, β and γ) , preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors. Anti-Retinoic Acid Receptor alpha antibody is tested for use in Western Blotting to detect a single band at approximately 48 kDa corresponding to expected molecular weight for RAR-α proteins in the appropriate cell lysate or extract. Researchers should determine optimal titers for applications that are not stated below.