Nuclear Pore Complex Antibody

Nuclear Pore Complex Antibody detects Nuclear Pore Complex proteins. The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus. Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) . Anti-Nuclear Pore Complex Antibody is ideal for investigators involved in Cancer and Immunology Research. Anti-Nuclear Pore Complex Antibody is tested for use in ICC/IF. Specific conditions for reactivity should be optimized by the end user