(S,R,S)-AHPC-Me (dihydrochloride)
Catalogue number:
HY-42424A-500mg
Supplier:
Size:
500 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2504950-56-3
Purity:
99.84
Molecular Formula:
C23H34Cl2N4O3S
Molecular Weight:
517.51
Mass Spectrometry:
Reference Materials
Alternative Names:
VHL ligand 2 (dihydrochloride); E3 ligase Ligand 1 (dihydrochloride)
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 [2].
