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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1948273-03-7
Purity:
99.59
Molecular Formula:
C23H33ClN4O3S
Molecular Weight:
481.05
Alternative Names:
VHL ligand 2 (hydrochloride); E3 ligase Ligand 1
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2].
