Siramesine (hydrochloride)
Catalogue number:
HY-14221A-50mg
Supplier:
Size:
50 mg
Product is available in:
£847.00
Special price until 31 Dec 2025
Normal price £941.00
Shipping is calculated in checkout
Normal price £941.00
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
224177-60-0
Purity:
99.74
Molecular Formula:
C30H32ClFN2O
Molecular Weight:
491.04
Alternative Names:
Lu 28-179 (hydrochloride)
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].
