Romaciclib (monohydrochloride)
Catalogue number:
HY-111388A-10mg
Supplier:
Size:
10 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2443816-41-7
Purity:
99.29
Molecular Formula:
C15H19Br2ClN4
Molecular Weight:
450.60
Mass Spectrometry:
Reference Materials
Alternative Names:
SEL120-34A (monohydrochloride)
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, with a Kd of 3 nM for CDK8. SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC50=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726[1]. Has anti-tumor activity[1].
