Laduviglusib (trihydrochloride)
Catalogue number:
HY-10182B-1mL
Supplier:
Size:
1 ml
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1782235-14-6
Purity:
99.11
Molecular Formula:
C22H21Cl5N8
Molecular Weight:
574.72
Mass Spectrometry:
Reference Materials
Alternative Names:
CHIR-99021 (trihydrochloride); CT99021 trihydrochloride
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy[1][2][3]. 10mM
