£411.00
Estimated delivery Fri 17 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
265312-55-8
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Weight:
284.3
Alternative Names:
2-methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione, cdk4 inhibitor iii, cyclic-dependent kinase 4 inhibitor iii, sps812
Product Description:
An inhibitor of SETD8 (IC50 = 0.5 µM) that suppresses monomethylation of H4K20 in vitro; less potently inhibits Cdk4 (IC50 = 6 µM for Cdk4/cyclin D1); suppresses the expression of Cdc7, resulting in an ATM-dependent checkpoint response and arrest of cell cycling in S phase
