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Trametinib

Supplier:
Catalogue number:
CAY16292-250 mg
Size:
250 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£309.00 Estimated delivery Tue 4 May
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An inhibitor of MEK1 and -2; inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively); inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM) and seven cell lines expressing mutant K-Ras (IC50s = 2.2-174 nM) but does not inhibit the growth of wild-type COLO 320DM cells expressing both B-RAF and K-Ras (IC50 = >10,000 nM); reduces tumor growth in HT-29 and COLO 205 mouse xenograft models at 0.3 and 1 mg/kg per day; decreases M. tuberculosis-induced increases in hind paw volume in a rat model of arthritis at 0.03 and 0.1 mg/kg per day

Product Type:

Biochemicals

CAS Number:

871700-17-3

Alternative Names:

n-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2h)-yl]phenyl]-acetamide, gsk1120212, jtp-74057

Storage Temp:

-20°C

Formulation:

A crystalline solid

Compound Purity:

≥95%

UNSPSC Code:

12352200

CAY16292-250 mg: Trametinib

CAY16292-250 mg: Trametinib