www.bioscience.co.uk
Sales & Support: +44 (0)1223 316 855

*

Proteinase 3, Human, ELISA kit

Catalogue number:
Supplier:
Size:
96 determinations _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£817.00 Shipping is calculated in checkout

Proteinase 3 (PR3) is a major antigen recognized by autoantibodies directed against cytoplasmic proteins of neutrophilic granulocytes and monocytes (so called anti-neutrophil cytoplasmic autoantibodies (ANCA)). ANCA are able to activate primed neutrophils to produce oxygen radicals and release lytic enzymes, including PR3. PR3 was identified as the target antigen of ANCA in Wegener's granulomatosis (WG). ANCA directed against PR3 (PR3-ANCA) can interfere with the binding of PR3 to its physiological inhibitor alpha1-antitrypsin (alpha1-AT) and with the proteolytic activity of PR3. At the site of inflammation PR3 can cleave the complex between these inhibiting ANCA and PR3 itself, leaving active PR3. Autoantibodies to PR3 are potent activators of the 5-lipoxygenase pathway in primed human neutrophils. Extracellular free arachidonic acid, as present at an inflammatory focus, synergizes with such autoantibodies to evoke full-blown lipid mediator generation, granule secretion and respiratory burst.PR3 is a neutral serine proteinase, which is localized in the azurophilic granules of neutrophils and in granules of monocytes and can be detected in the membrane of secretory vesicles. PR3 degrades a number of extracellular matrix proteins such as elastin and inactivates human C1 inhibitor. Membrane-associated PR3 is also able to activate caspase-3 without triggering apoptosis of neutrophils, which is possibly a neutrophil survival mechanism. In addition, PR3 is involved in myeloid differentiation and is, therefore, also called myeloblastin. PR3 matures/activates major inflammatory cytokines like membrane bound TNF, IL1beta and IL18. It has an important role in inflammasome-independent induction of inflammation and an important role in inflammatory diseases as Reumatoid Arthritis, IBD and inflammatory-associated disease as Type 2 diabetes, cardiovascular diseases and artherosclerosis.

image 0
image 1
HK384-01 Proteinase 3, Human, ELISA kit
HK384-01 Proteinase 3, Human, ELISA kit
HK384-01 Proteinase 3, Human, ELISA kit
HK384-01 Proteinase 3, Human, ELISA kit
Details Cat number & supplier Size Price
HNP1-3, Human, ELISA kit HK317-02 · Hycult Biotech
HK317-02
Hycult Biotech
2 x 96 determinations £1345.00
2 x 96 determinations
view
Elastase, Human, ELISA kit HK319-02 · Hycult Biotech
HK319-02
Hycult Biotech
2 x 96 determinations £1210.00
2 x 96 determinations
view
LBP, various species, ELISA kit HK503 · Hycult Biotech
HK503
Hycult Biotech
96 determinations £1087.00
96 determinations
view
MPO, Rat, ELISA kit HK105-01 · Hycult Biotech
HK105-01
Hycult Biotech
96 determinations £817.00
96 determinations
view
MPO, Mouse, ELISA kit HK210-01 · Hycult Biotech
HK210-01
Hycult Biotech
96 determinations £817.00
96 determinations
view
LBP, Human, ELISA kit HK315-01 · Hycult Biotech
HK315-01
Hycult Biotech
96 determinations £748.00
96 determinations
view
HNP1-3, Human, ELISA kit HK317-01 · Hycult Biotech
HK317-01
Hycult Biotech
96 determinations £817.00
96 determinations
view
Elastase, Human, ELISA kit HK319-01 · Hycult Biotech
HK319-01
Hycult Biotech
96 determinations £748.00
96 determinations
view
LL-37, Human, ELISA kit HK321-01 · Hycult Biotech
HK321-01
Hycult Biotech
96 determinations £817.00
96 determinations
view
MPO, Human, ELISA kit HK324-01 · Hycult Biotech
HK324-01
Hycult Biotech
96 determinations £748.00
96 determinations
view