Insulin β Chain Peptide (15-23)

This is amino acids 15 to 23 fragment of the insulin β chain recognized by islet-associated T cells. This peptide is also known as INS. It was used in diabetes studies to assay the IFN-β and IL-17 production by diabetogenic CD4 or CD8 T cells. This peptide stains the INS-reactive CTL clone, but doesn’t stain the splenic CD8+ T cells from NOD or 8.3-TCR-transgenic NOD mice.