www.bioscience.co.uk
Sales & Support: +44 (0)1223 316 855

*

TCC, Rat, ELISA kit

Catalogue number:
Supplier:
Size:
2 x 96 determinations _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£1345.00 Shipping is calculated in checkout

The three distinct activation pathways of complement converge with the formation of a C5 convertase and it is cleavage of C5 by these convertases that initiates the lytic or terminal pathway. In contrast to the activation pathways, which require enzymatic cleavage for activation, the terminal pathway relies on conformational changes induced by binding. Binding of C6 facilitates binding of C7 which alters the conformation of the complex.After binding of C8 a variable number of C9 molecules associate with the C5b678 complex, the so called terminal complement complex (TCC) or Membrane Attack Complex (MAC). The formation of the membrane form of TCC causes lysis of cells or can trigger a variety of cellular metabolic pathways resulting in the synthesis and release of inflammatory mediators. The TCC contains neoantigens that are absent from the individual native components. Neoantigens are present both in the membrane-bound (MAC) and the fluid-phase (SC5b-9) complex. TCC is present in normal human plasma, < 1 AU/ml, and increases in patients with complement activation.

image 0
image 1
HK106-02 TCC, Rat, ELISA kit
HK106-02 TCC, Rat, ELISA kit
HK106-02 TCC, Rat, ELISA kit
HK106-02 TCC, Rat, ELISA kit
Details Cat number & supplier Size Price
Factor H, 402H/Y variant detection, Human, ELISA kit HK353 · Hycult Biotech
HK353
Hycult Biotech
96 determinations £885.00
96 determinations
view
MBL, Human, ELISA kit HK323-01 · Hycult Biotech
HK323-01
Hycult Biotech
96 determinations £748.00
96 determinations
view
Complement factor H, Human, ELISA kit HK342-01 · Hycult Biotech
HK342-01
Hycult Biotech
96 determinations £817.00
96 determinations
view
MBL, Human, ELISA kit HK323-02 · Hycult Biotech
HK323-02
Hycult Biotech
2 x 96 determinations £1210.00
2 x 96 determinations
view
Complement factor H, Human, ELISA kit HK342-02 · Hycult Biotech
HK342-02
Hycult Biotech
2 x 96 determinations £1345.00
2 x 96 determinations
view
C1q, Mouse, ELISA kit HK211-01 · Hycult Biotech
HK211-01
Hycult Biotech
96 determinations £817.00
96 determinations
view
C1q, Mouse, ELISA kit HK211-02 · Hycult Biotech
HK211-02
Hycult Biotech
2 x 96 determinations £1345.00
2 x 96 determinations
view
TCC, Human, ELISA kit HK328-01 · Hycult Biotech
HK328-01
Hycult Biotech
96 determinations £748.00
96 determinations
view
TCC, Human, ELISA kit HK328-02 · Hycult Biotech
HK328-02
Hycult Biotech
2 x 96 determinations £1210.00
2 x 96 determinations
view
Properdin, Human, ELISA kit HK334-01 · Hycult Biotech
HK334-01
Hycult Biotech
96 determinations £817.00
96 determinations
view