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1245653-57-9
≥90%
A crystalline solid
595.7
3-[[[(1s,3s)-3-carboxycyclohexyl]amino]carbonyl]-4-[3-[4-[4-(cyclohexyloxy)butoxy]phenyl]propoxy]-benzoic acid
- Data sheet: View or download
- MSDS: View or download
A CysLT2 receptor antagonist (IC50 = 37.9 nM in a radioligand binding assay); selective for CysLT2 over CysLT1 (IC50 = >30 µM in a radioligand binding assay); inhibits LTD4- or LTC4-induced calcium mobilization in CHO cells expressing human CysLT2 (IC50s = 3.8 and 4.4 nM, respectively); reverses the LTC4-induced increases in perfusion pressure and decreases in contractility in isolated Langendorff-perfused guinea pig hearts; prevents decreases in body weight and neurological deficit scores in a rat model of S. pneumoniae-induced meningitis at 0.1 mg/kg; as well as reduces infarct volume in a rat model of MCAO-induced cerebral ischemia brain injury at 0.1 mg/kg; prevents increases in airway hyperresponsiveness in a mouse model of ovalbumin-induced asthma at 10 mg/kg
-20°C
