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MPO, Mouse, ELISA kit

Supplier:
Catalogue number:
HK210-02
Size:
2 x 96 detections
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£1078.00 Estimated delivery Thu 3 Feb
Shipping is calculated in checkout

The monoclonal antibody MaP.VIP recognizes mouse Viperin, a 42 kDa protein belonging to the RSAD2 family. Viperin is the abbreviation of Virus inhibitory protein endoplasmic reticulum-associated interferon-inducible. It is an evolutionary conserved protein that is highly inducible by both type I and type II interferons. However, little or no induction by interferon gamma is observed in monocytic cell lines. Infection by many viruses, including human cytomegalovirus (hCMV), hepatitis C virus, yellow fever virus and Sendai virus, strongly induces viperin expression, suggesting a role in the host antiviral response. Viperin has also been shown to be important for the host anti-HIV responses. Furthermore, expression of viperin inhibits influenza replication by perturbing its release from the plasma membrane. Viperin expression alters plasma membrane fluidity by affecting formation of lipid rafts which are detergent-resistant membrane microdomains known to be the sites of influenza virus budding. HCMV infection induces the redistribution of viperin from the endoplasmic reticulum to the Golgi complex and ultimately to cytoplasmic vacuoles, suggesting that viperin may function at a distinct level in the viral lifecycle, at the point of glycosylated viral protein transport.

Product Type:

ELISAs

Species Reactivity:

Rat - Weak

Storage Temp:

Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at lea

UNSPSC Code:

41116126

HK210-02 MPO, Mouse, ELISA kit

HK210-02 MPO, Mouse, ELISA kit

HK210-02 MPO, Mouse, ELISA kit

HK210-02 MPO, Mouse, ELISA kit

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