TNF-α
Catalogue number:
GFH111-10
Supplier:
Size:
10 µg
Product is available in:
Purity:
>95% determined by reducing and non-reducing SDS-P
Molecular Weight:
17.5
Alternative Names:
Tumor Necrosis Factor ?, TNFa, TNF?, TNFSF2, cachectin, DIF, necrosin, cytotoxin, cachexin, TNF
- Data sheet: View or download
- MSDS: View or download
Product Description:
Tumor Necrosis Factor α (TNF-α) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T cells, and Natural Killer (NK) cells following stimulation by bacterial lipopolysaccharide (LPS). TNF-α signal activation occurs through two receptors, TNFR1 and TNFR2. TNFR1 is expressed on most cell types, unlike TNFR2, which is expressed mainly on immune cells. TNF-α functions to stimulate phagocytosis in macrophages, chemoattract neutrophils, increase insulin resistance, and induce fever.