CTGF

Connective Tissue Growth Factor (CTGF) is a mitogen that is secreted by vascular endothelial cells in response to basic fibroblast growth factor (FGF-2) or vascular endothelial growth factor (VEGF). CTGF promotes cell growth, migration, adhesion, and survival of endothelial cells. CTGF is also important during osteogenesis, chondrogenesis, and skeletogenesis. CTGF has an insulin-like growth factor binding protein (IGFBP) domain, a thrombospondin type 1 repeat (TSR) domain, and a C-terminal cysteine knot motif.

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