AMG-548
Catalogue number:
HY-108642-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
864249-60-5
Purity:
99
Molecular Formula:
C29H27N5O
Molecular Weight:
461.56
Alternative Names:
AMG-548
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
AMG-548, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM)[1]. AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε[2].