Narazaciclib
Catalogue number:
HY-12624-100mg
Supplier:
Size:
100 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1357470-29-1
Purity:
98.66
Molecular Formula:
C24H27N7O
Molecular Weight:
429.52
Mass Spectrometry:
Reference Materials
Alternative Names:
ON123300
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Narazaciclib (ON123300), a strong and brain-penetrant[1] multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRβ (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent Narazaciclib causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors[2]. Narazaciclib inhibits CDK6 with an IC50 of 9.82 nM[3].