Capmatinib
Catalogue number:
HY-13404-100mg
Supplier:
Size:
100 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1029712-80-8
Purity:
99.82
Molecular Formula:
C23H17FN6O
Molecular Weight:
412.42
Mass Spectrometry:
Reference Materials
Alternative Names:
INC280; INCB28060
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase[1][2][3].