Quizartinib
Catalogue number:
HY-13001-50mg
Supplier:
Size:
50 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
950769-58-1
Purity:
99.08
Molecular Formula:
C29H32N6O4S
Molecular Weight:
560.67
Mass Spectrometry:
Reference Materials
Alternative Names:
AC220; AC708
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis[1].