FzM1
Catalogue number:
HY-116553-50mg
Supplier:
Size:
50 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1680196-54-6
Purity:
98.72
Molecular Formula:
C21H16N2O2S
Molecular Weight:
360.43
Mass Spectrometry:
Reference Materials
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh= 6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade[1][2].