Telaglenastat
Catalogue number:
HY-12248-50mg
Supplier:
Size:
50 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1439399-58-2
Purity:
99.92
Molecular Formula:
C26H24F3N7O3S
Molecular Weight:
571.57
Mass Spectrometry:
Reference Materials
Alternative Names:
CB-839
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity[1].