ONX-0914
Catalogue number:
HY-13207-25mg
Supplier:
Size:
25 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
960374-59-8
Purity:
99.72
Molecular Formula:
C31H40N4O7
Molecular Weight:
580.67
Mass Spectrometry:
Reference Materials
Alternative Names:
PR-957
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 µM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1[1][2][3].