Bisindolylmaleimide III
Catalogue number:
HY-117393-10mg
Supplier:
Size:
10 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
Molecular Formula:
C23H20N4O2
Molecular Weight:
384.43
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- MSDS: View or download
- Protocol: View or download
Product Description:
Bisindolylmaleimide III is a protein kinase C (PKC) inhibitor with IC50 values of 0.26, 5.7, and 6 µM against PKCα, PKCδ, and PKCµ, respectively. Bisindolylmaleimide III also exhibits inhibitory activity against other off-targets, with IC50 values of 0.17, 1, and 2 µM against SLK, adenosine kinase (AK), and CDK2, respectively; its Ki for NQO2 is 16.5 µM. Bisindolylmaleimide III selectively binds to activated Rsk1 following EGF stimulation, and serves as a tool for detecting the activation status of intracellular Rsk1 and PKCα, as well as for functional analysis of SLK. Bisindolylmaleimide III can be used in studies of signal transduction and colorectal cancer[1][2][3].