AFN-1252
Catalogue number:
HY-16911-10mg
Supplier:
Size:
10 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
620175-39-5
Purity:
99.49
Molecular Formula:
C22H21N3O3
Molecular Weight:
375.42
Mass Spectrometry:
Reference Materials
Alternative Names:
API-1252; Debio 1452
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
AFN-1252 is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC90 values of ⩽0.015 µg/ml against diverse clinical isolates of S. aureus. AFN-1252 is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith[1][2].