Acalabrutinib
Catalogue number:
HY-17600-10mg
Supplier:
Size:
10 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1420477-60-6
Purity:
99.88
Molecular Formula:
C26H23N7O2
Molecular Weight:
465.51
Mass Spectrometry:
Reference Materials
Alternative Names:
ACP-196
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL)[1][2]. Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.