Lofepramine
Catalogue number:
HY-12390-10mg
Supplier:
Size:
10 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
23047-25-8
Purity:
99.0
Molecular Formula:
C26H27ClN2O
Molecular Weight:
418.96
Mass Spectrometry:
Reference Materials
Alternative Names:
Lopramine
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 µM and 11 µM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. [1][2][3][4].