D-α-Hydroxyglutaric acid (disodium)
Catalogue number:
HY-100542-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
103404-90-6
Purity:
98.0
Molecular Formula:
C5H6Na2O5
Molecular Weight:
192.08
Mass Spectrometry:
Reference Materials
Alternative Names:
Disodium (R)-2-hydroxyglutarate
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- MSDS: View or download
- Protocol: View or download
Product Description:
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5].