Hydrastine
Catalogue number:
HY-B0927-5mg
Supplier:
Size:
5 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
118-08-1
Purity:
99.57
Molecular Formula:
C21H21NO6
Molecular Weight:
383.39
Alternative Names:
(-)-β-Hydrastine; (1R,9S)-β-Hydrastine
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 µM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 µM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage[1][2].