Dolutegravir
Catalogue number:
HY-13238-1ml
Supplier:
Size:
1 ml
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1051375-16-6
Purity:
99.85
Molecular Formula:
C20H19F2N3O5
Molecular Weight:
419.38
Mass Spectrometry:
Reference Materials
Alternative Names:
S/GSK1349572
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2]. 10mM