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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
880487-62-7
Purity:
98
Molecular Formula:
C18H15N5O
Molecular Weight:
317.34
Mass Spectrometry:
Reference Materials
- Data sheet: View or download
- MSDS: View or download
Product Description:
Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 µM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells[1][2].