Verrucarin A
Catalogue number:
HY-107426-1mg
Supplier:
Size:
1 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
3148-09-2
Purity:
99.89
Molecular Formula:
C27H34O9
Molecular Weight:
502.55
Mass Spectrometry:
Reference Materials
Alternative Names:
Muconomycin A
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53[1][2].