Borrelidin
Catalogue number:
HY-N6742-1mg
Supplier:
Size:
1 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
7184-60-3
Purity:
99.80
Molecular Formula:
C28H43NO6
Molecular Weight:
489.64
Alternative Names:
Treponemycin
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- MSDS: View or download
- Protocol: View or download
Product Description:
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei[1]. Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 µM[2]. Borrelidin is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells[3]. Borrelidin has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively[4].