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CAS Number:
890190-22-4
Purity:
99.93
Molecular Formula:
C21H25N3O4
Molecular Weight:
383.44
Mass Spectrometry:
Reference Materials
Alternative Names:
WD-Repeat Protein 5-0103
- Data sheet: View or download
- MSDS: View or download
Product Description:
WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM. IC50 value: 450 nM (Kd) Target: WDR5 in vitro: WDR5-0103 inhibits MLL catalytic activity with an IC50 value of 39±10 µM. An increase in MLL complex concentration resulted in proportional increase in IC50 values for WDR5-0103 (83±10 and 280±12 µM at concentrations of 500 and 1000 nM of the core trimeric MLL complex respectively). These data are consistent with a mechanism of action in which WDR5-0103 antagonizes the interaction of WDR5 with MLL by competing with MLL for their mutual binding site on WDR5.